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KMID : 0361020230660050295
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Korean Journal of Otolaryngology - Head and Neck Surgery
2023 Volume.66 No. 5 p.295 ~ p.301
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The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer
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Han Myung-Woul
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Abstract
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Radiotherapy plays an important role in the treatment of most of solid tumors including headand neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recur-rence and distant metastases. Despite significant progress in research of radioresistance, itsprediction and overcoming strategies remain challenging. This review describes the potentialbiomarkers correlated to the radioresistance and complex signal pathway in mechanism of ra-dioresistance focusing on the PI3K and EphA3 pathway.
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KEYWORD
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Head and neck cancer, PI3K/AKT pathway, Radioresistance, Receptor EphA3
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